Erhaltung mit Lena (HD7)

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KaMö60 antwortete auf Erhaltung mit Lena (HD7)

12 Jan. 2022 15:40

KaMö60
Offline

36 Beiträge seit
24 Februar 2021

Mehr

Hallo Maennes,
meine Familie meint, meine Genesung stagniert.
Na, ja. Meine Blutwerte befinden sich entweder über oder unter der Norm, so geht es seit der HC und Stamm.. Therapie.
Physisch habe ich es mit einer Atemnot zu tun, ohne Rollator geht da wenig. Bin jetzt in Rente, könnte auch unmöglich arbeiten.
Am 18.1 ist wieder Blutkontrolle, da werde ich die Dosis mit Revlimid ansprechen.
Das MM ist so vielseitig in den Auswirkungen, deshalb sucht man wohl in der Therapie nach dem kleinsten Übel.
Was soll ich sagen, es geht auch schlimmer.
Halt wir alle den Kopf weiter hoch!

Gruß Karsten

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maennes antwortete auf Erhaltung mit Lena (HD7)

11 Jan. 2022 10:02

maennes
Autor
Offline

17 Beiträge seit
10 Dezember 2019

Mehr

Hi,
bin aktuell auf 5mg alle 2 Tage... Mehr geht nicht. Meine neutrophile machen das nicht mit.
Ansonsten bin ich zufrieden, es geht mir gut.
Man muss einfach lernen, den Tag zu genießen und das jeden und jeden Tag wieder...
Vg

P. S. Hast du sonst Probleme? Wie geht es dir?

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KaMö60 antwortete auf Erhaltung mit Lena (HD7)

09 Jan. 2022 18:00

KaMö60
Offline

36 Beiträge seit
24 Februar 2021

Mehr

Hallo Maennes,
mein MM Werdegang sieht auch so aus.
Reduzierung von 10 mg auf 5 mg Revlimid. Habe die 10 mg einfach nicht vertragen.
Wie geht es dir jetzt?
Gruß

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Stefmyel antwortete auf Erhaltung mit Lena (HD7)

06 Dez. 2021 15:26

Stefmyel
Offline

57 Beiträge seit
20 Juni 2019

Mehr

Hallo maennes,
leider lese ich deinen Beitrag erst jetzt. Sehr interessant, wir haben beinahe vollständig den selben Verlauf. Gleicher Zeitpunkt der Therapien, Gleiche Studie (nur bin ich im Studienarm ohne Antikörper) und bin ca. 8 Jahre älter als du.
Was das Absinken der neutrophilen Granulozyten anbelangt, ist bei mir identisch! Deshalb hat man nach paar Monaten Erhaltung die Dosis von 15 mg auf 10 mg reduziert. Mein Blutbild wird einmal pro Woche kontrolliert, und immer wenn die neutrophilen unter den Wert "1" sinken, wird Revlimid pausiert. Im Moment kann ich ca 3-4 Wochen Revlimid einnehmen und muss dann für ca. 7-14 Tage pausieren. Bin auch etwas verunsichert deswegen. Auch die Leukos sind natürlich chronisch tief (zw. 2 u 3). Spüren tue ich von all dem nichts, fühle mich fit und mache - wie schon vor meiner Therapie sehr viel Sport...
Wie ist denn eigentlich dein Stand aktuell? Dein Beitrag liegt einige Zeit zurück....
Liebe Grüße
Stefan

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Deprecated: Creation of dynamic property Kunena\Forum\Libraries\User\KunenaUser::$whatsapp is deprecated in /www/htdocs/w0185eeb/myelom.villa-ester.de/libraries/kunena/src/User/KunenaUser.php on line 700

Deprecated: Creation of dynamic property Kunena\Forum\Libraries\User\KunenaUser::$weibo is deprecated in /www/htdocs/w0185eeb/myelom.villa-ester.de/libraries/kunena/src/User/KunenaUser.php on line 700

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Deprecated: Creation of dynamic property Kunena\Forum\Libraries\User\KunenaUser::$apple is deprecated in /www/htdocs/w0185eeb/myelom.villa-ester.de/libraries/kunena/src/User/KunenaUser.php on line 700

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Deprecated: Creation of dynamic property Kunena\Forum\Libraries\User\KunenaUser::$bebo is deprecated in /www/htdocs/w0185eeb/myelom.villa-ester.de/libraries/kunena/src/User/KunenaUser.php on line 700

Deprecated: Creation of dynamic property Kunena\Forum\Libraries\User\KunenaUser::$socialshare is deprecated in /www/htdocs/w0185eeb/myelom.villa-ester.de/libraries/kunena/src/User/KunenaUser.php on line 700
maennes antwortete auf Erhaltung mit Lena (HD7)

08 Apr. 2021 06:43

maennes
Autor
Offline

17 Beiträge seit
10 Dezember 2019

Mehr

Hi Triple M,
danke für den Beitrag, der Artikel ist schon mal informativ!
VG

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Triple M antwortete auf Erhaltung mit Lena (HD7)

07 Apr. 2021 17:59

Triple M
Offline

61 Beiträge seit
30 Juni 2017

Mehr

Hallo maennes,

schau mal hier (in englischer Sprache):

clincancerres.aacrjournals.org/content/26/22/5879

In dieser Studie wurde die Wirksamkeit und Verträglichkeit von Lena Erhaltungstherapie in der Dosierung von 5mg/d versus anfänglich 25 mg/d (am Ende aber wegen notwendiger Dosisreduzierung auch nur durchschnittlich 15mg/d) verglichen.

Fazit:
Die Dosierung 5mg/d ist definitiv wirksam (entgegen Deinen Befürchtungen!!!). Mehr ist aber besser, sofern man es denn verträgt. (Hätte man vielleicht auch vermuten können...) Man sollte daher laut den Studienautoren versuchen, sich an seine individuelle Maximaldosis heranzutasten, indem man es immer wieder mit einer Höherdosierung versucht (ggf. auch unter Einsatz von Wachstumsfaktoren, um die Leukos zu pushen?! - Dies wurde in der Studie offenbar auch, wenn auch zurückhaltend eingesetzt......)

Ich würde an Deiner Stelle erstmal mitnehmen, dass 5mg/d keineswegs nutzlos sind, sondern im Gegenteil die gewünschte positive Wirkung entfalten. Und wer weiß, vielleicht muss es in Verbindung mit Isatuximab ja auch gar nicht mehr sein - das hat ja bisher schließlich noch niemand untersucht....

Viele Grüße und viel Erfolg bei Deiner weiteren Therapie
Triple M

n = 1

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